● Autophagy.（IF=13.391）.Ruolin Li, et.al.（2021）. Piperine promotes autophagy flux by P2RX4 activation in SNCA/α-synuclein-induced Parkinson disease model.［首都医科大学 SNCA过表达质粒 自噬、帕金森病］

● NATURE COMMUNICATIONS.（IF=17.694）. Xiaolong Tang, et.al.（2021）. Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis .［浙江大学 FLAG-AMPKα1 & FLAG-SKP2 & FLAG-AKT1过表达质粒 恶性肿瘤］

● NATURE COMMUNICATIONS.（IF=17.694）. Lijuan Zhang，et.al.（2021）. Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage Polarization .［天津医科大学Myc-IkBa & HA-UB K48 巨噬细胞］

● J Immunother Cancer.（IF=12.469）. Rui Qin，et.al.（2021）. Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation ［复旦大学 NFATc过表达质粒 色氨酸免疫激活］

● Genome Biology.（IF=17.906）. Xujia Wu，et.al.（2021）.A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity［中山大学第一附属医院 PTCH1 & Gli1过表达质粒 胶质母细胞瘤］

●  Neuro-Oncology. （IF=13.029）. Kaikai Yi，et.al.（2021）.PTRF/cavin-1 remodels phospholipid metabolism to promote tumor proliferation and suppress immune responses in glioblastoma by stabilizing cPLA2 . [天津医科大学 PTRF过表达质粒 胶质母细胞瘤]

●  EMBO Molecular Medicine.（IF=14.260）. Xujia Wu，et.al.（2021）.Nanog maintains stemness of Lkb1-deficient lung adenocarcinoma and prevents gastric differentiation. [中国科学院NANOG过表达质粒 肺癌]

●  Cell Death & Disease.(IF=6.304) .Hao et al. (2020) .Dual regulation of p53 by the ribosome maturation factor SBDS. ［复旦大学 SBDS过表达质粒 肺癌和结肠癌］

●  Cell Death & Disease.(IF=6.304) .Fu et al. (2020) .Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression. ［香港浸会大学 TLR4过表达质粒 黑色素瘤］

●  Biochemical Pharmacology.(IF=4.96) .Li et al. (2020) .Downregulation of OCTN2 by Cytokines Plays an Important Role in the Progression of Inflammatory Bowel Disease. ［浙江大学 SLC22A5过表达质粒 HT29&FHC cells 炎症性肠病IBD］

●  Cancer Letters.(IF=7.36) .Liu et al. (2020) .MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma. ［中南大学湘雅医院 MYH9过表达质粒 肺癌细胞］

●  Cancer Letters.(IF=7.36) .Luo et al. (2019) .DMBX1 promotes tumor proliferation and regulates cell cycle progression via repressing OTX2-mediated transcription of p21 in lung adenocarcinoma cell. ［江苏省肿瘤医院 肺癌细胞］

●  Redox Biology.(IF=9.986) .Tian et al. (2019) .aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1.［华中科技大学同济医学院附属同济医院 PRKCI & KEAP1表达质粒 胆囊癌］

●  Phytomedicine. (IF 7.9). Pan et.al. (2023). Synergistic neuroprotective effects of two natural medicinal plants against CORT-induced nerve cell injury by correcting neurotransmitter deficits and inflammation imbalance. [山东中医药大学中医学院 miRNA-144-3p过表达和干扰质粒 神经]

●  Pharmacological Research.(IF=5.893) .Huang et al. (2020) .MiR-377-3p suppresses colorectal cancer through negative regulation on Wnt/β-catenin signaling by targeting XIAP and ZEB2.［华中科技大学同济医学院附属同济医院 mir377过表达质粒 结直肠癌］

●  PPAR Research.(IF=2.953) .Xu et al. (2019) .Peroxisome Proliferator-Activated Receptor-γ Antagonizes LOX-1-Mediated Endothelial Injury by Transcriptional Activation of miR-590-5p.［复旦大学附属中山医院 mir590过表达质粒 内皮损伤］

●  Theranostics.(IF=8.579) .Song et al. (2019) .Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction.［华中科技大学同济医学院附属同济医院mir21过表达质粒 急性心肌梗死MI］

●  J Immunother Cancer.（IF=12.469）. Qi- Hua Peng，et.al.（2021）.CMTM6 and PD- L1 coexpression is associated with an active immune microenvironment and a favorable prognosis in colorectal cancer. ［中山大学 pEnter- CMTM6- Flag过表达质粒 直肠癌］

●  Cell Death Dis. (IF=6.304). Ma, et al. (2020). circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS.［江苏省肿瘤医院 pAV-circRNA 5615 结直肠癌］

●  Toxicol. Appl. Pharmacol. (IF=3.347). Ge & Tu, et al. (2020). MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1.［上海市第一人民医院 & 上海交通上海交通大学医学院 pcDNA3.1-FLAG-CCAR1 放射性直肠损伤］

●  Cell Death Dis. (IF=6.304). Zhang, et al. (2019). circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA.［上海交通大学医学院 pADM-circHIPK3-GFP 肺纤维化］

●  Int J Med Sci. (IF=2.523). Wang, et al. (2019). LncRNA SNHG6 promotes proliferation, invasion and migration in colorectal cancer cells by activating TGF-β/Smad signaling pathway via targeting UPF1 and inducing EMT via regulation of ZEB1.［南方医科大学 pCMV-SNHG6 结直肠癌］

●  EBioMedicine. (IF=5.736). Jiang, et al. (2019). Overexpression of PIMREG promotes breast cancer aggressiveness via constitutive activation of NF-κB signaling.［广州医科大学 HA-tagged full-length p65 and the truncated p65 fragments plasmids 乳腺癌］

●  Aging (Albany NY). (IF=4.831). Li, et al. (2019). Sirt1-inducible deacetylation of p21 promotes cardiomyocyte proliferation.［南方医科大学南方医院 pcDNA3.1-FLAG-p21 WT & pcDNA3.1-FLAG-p21 KR & pcDNA3.1-FLAG-p21 KQ 心肌细胞增殖］

●  R Soc Open Sci. (IF=2.647). Liu, et al. (2018). Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS.［浙江大学医学院附属第一医院pSH-U6-miR-143-5p-gRNA(or miR-143-3p-gRNA/miR-145-5p-gRNA/miR145-3p-gRNA)-CMV-SpCas9-P2A-Puro 人表皮角质细胞HEKs 尖锐湿疣(CA)］

● Biol Psychiatry. (IF=12.095). Zhao D, et al. (2019). RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits.［厦门大学 Ad-PSD-95 & Ad-control GFP 阿尔兹海默症］

● J Clin Endocrinol Metab. (IF=5.399). Li M, et al. (2019). The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome.［山东大学 Ad-HMGA2 多囊卵巢综合征］

● Int J Cardiol. (IF=3.229). Wu B, et al. (2018). Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling.［湖北医药学院 Ad-Meox1 血管重塑］

● Life Sci. (IF=6.304). He M, et al. (2018). In vitro study of FUZ as a novel potential therapeutic target in non-small-cell lung cancer.［北京大学 Ad-FUZ & Ad-NC 非小细胞肺癌］

● Cell Death Dis. (IF=6.304). Sun S, et al. (2017). Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming.［华中科技大学同济医学院附属同济医院 Ad-PDK4 肿瘤代谢］

● Molecular Medicine Reports. (IF=2.1). Zhang S, et al. (2017). PAR1-mediated c-Jun activation promotes heat stress-induced early stage apoptosis of human umbilical vein endothelial cells. ［南方医科大学南方医院 Ad-PAR1 热应激诱导HUVEC凋亡］

● Hepatology. (IF=14.679). Xiang D, et al. (2017). Shp2 promotes liver cancer stem cell expansion by augmenting β-atenin signaling and predicts chemotherapeutic response of patients.［东方肝胆外科医院 AdShp2 and AdGFP 肝癌］

● Cancer Letters. (IF=7.36). Wang Z , et al . (2017). CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrinβ1/FAK/AKT signaling.［中山大学附属第一医院 Ad-CXCL1胃癌］

● Gene. (IF=2.984). Zhang J W, et al. (2017). Validation of aspirin response-related transcripts in patients with coronary artery disease and preliminary investigation on CMTM5 function.［北京大学第一医院 Ad-CMTM5-v1& Ad-mock 冠心病］

● Cell Death Dis. (IF=6.304). Zheng Y, et al. (2017). Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy. ［上海交通大学医学院 & 中国科学院上海生命科学研究院 Ad-Atg5 缺血性心脏病］

● Oncoimmunology. (IF=5.869). Wang H, et al. (2016). Interactions between colon cancer cells and tumor-infiltrated macrophages depending on cancer cell-derived colony stimulating factor 1. ［山东齐鲁医院 Ad-hCSF1瘤内注射 结肠癌］

● Basic Res Cardiol. (IF=11.981). Sun Z, et al. (2016). Cross-talk between macrophages and atrial myocytes in atrial fibrillation.［浙江大学医学院附属第一医院 Ad-QKI 心房纤颤］

● Mol Carcinog. (IF=3.825). Wang J, et al. (2016). Endothelial cell-anchored tissue factor pathway inhibitor regulates tumor metastasis to the lung in mice.［复旦大学 Ad-TFPI & Ad-GFP 肿瘤］

● Frontiers in Immunology. (IF 8.786). Huang et.al. (2023). FGL2 deficiency alleviates maternal inflammation-induced blood-brain barrier damage by blocking PI3K/NF-kB mediated endothelial oxidative stress. [华中科技大学同济医学院附属同济医院 Ad-FGL2-miRNA 血脑屏障]

● Hypertension. (IF=9.897).Junni Wang，et.al.（2021）.MicroRNA-87 4-3p/ADAM (A Disintegrin and Metalloprotease) 19 Mediates Macrophage Activation and Renal Fibrosis After Acute Kidney Injury. [浙江大学第一附属医院 Ad-miR-874-3p 肾纤维化]

● Stem Cells Int. (IF=3.869). Li X, et al. (2019). MicroRNA-150 Modulates Adipogenic Differentiation of Adipose-Derived Stem Cells by Targeting Notch3.［中国医科大学 Ad-miR-150 脂肪源性干细胞］

● Oncotarget. (IF=5.168). Tian S, et al. (2017). miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1.［贵州医科大学附属医院 Ad-miR-138-5p & Ad-miR-NC 胰腺癌细胞自噬］

●Journal of Molecular Medicine，（IF 5.606）. Shao SY.（2023）. Never in mitosis gene Arelated kinase6 deficiency deterioratesdiabetic cardiomyopathy via regulating heat shock protein 72.［郑州大学第一附属医院Ad-NEK6，MOI=50，心肌细胞，糖尿病心肌病］

●Signal Transduction and Targeted Therapy（IF 39.3）.Chunsik Lee. et.al.（2023）. VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway［中山大学中山眼科中心，瑞典卡罗林斯卡研究院联合复旦大学附属眼耳鼻喉科医院Ad-FGFR1 WT，Ad-FGFR1 Y463F, Ad-FGFR1 Y585F，Ad-FGFR1 Y653F人脐静脉内皮细胞-HUVECs，MOI=10，血管］

●iScience （IF 6.107）.Li YJ.（2023）.Phosphodiesterase type 10A inhibitor attenuates lung 1 fibrosis by targeting myofibroblast activation［浙江大学医学院附属邵逸夫医院 pADM-PDE10A，人胚肺成纤维细胞（HFL-1），肺部纤维化］

●ISCIENCE. (IF 6.107). Guo et.al. (2023). Steroidogenic factor 1 protects mice from obesity-induced glucose intolerance via improving glucose-stimulated insulin secretion by beta cells. [中山大学附属第一医院 AAV和腺病毒过表达载体 胰腺]

●Journal of Translational Medicine. (IF=8.44). Zhang RN, et.al. (2023). The spatiotemporal matching pattern of Ezrin/Periaxin involved in myoblast differentiation and fusion and Charcot-Marie-Tooth disease-associated muscle atrophy.［湖北医药学院 Ad-NFATc1、Ad-NFATc2、Ad-shNFATc3、Ad-shNFATc4、Ad-Null 腓骨肌萎缩症］

●J CELL COMMUN SIGNAL.（IF=5.908）.Liu X, et.al. (2023). Sam68 promotes osteogenic differentiation of aortic valvular interstitial cells by TNF‑α/STAT3/autophagy axis.［武汉协和医院 Ad-Sam68 钙化主动脉瓣疾病］

●Journal of Nutritional Biochemistry.（IF=6.117）Liu J, et.al. (2023). Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction.［华中科技大学同济医学院公共卫生学院 Ad-Frataxin 酒精性肝病］

●Acta Pharmacologica Sinica. (IF 7.169) Guo et.al. (2023). JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit. [山东第一医科大学 JMJD6 腺病毒过表达载体 心肌肥厚]

●Journal of Neuroinflammation. (IF 9.587) Qian Xia et.al. (2022). Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1. [华中科技大学同济医院 SIRT5腺病毒过表达和干扰载体 神经炎症]

●Ecotoxicology and Environmental Safety. (IF 7.129) Jingjing Zhang et.al. (2023). The inhibition of TRPML1 TFEB leads to lysosomal biogenesis disorder contributes to developmental fluoride neurotoxicity. [新疆石河子大学 TFEB腺病毒过表达载体 氟神经毒性]

●ARTERIOSCL THROM VAS（IF=10.514）.Shu Liu，et.al.（2022）.Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein ［中国医学科学院阜外医 AdV-TPRG1-AS1和AdVMYH9 动脉粥样硬化］

●Journal of Cachexia, Sarcopenia and Muscle.（IF=12.063）.You W , et.al. (2022). Growth arrest and DNA damage-inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha.［浙江大学动物科学学院 Ad-GADD45A 肌内脂肪沉积］

● Free Radical Biology and Medicine. (IF 8.101). Liu Y, et.al. (2022). LRRK2 deficiency protects the heart against myocardial infarction injury in mice via the P53/HMGB1 pathway.［郑州大学第一附属医院 Ad-LRRK2 & Ad-LRRK2 D1994A & Ad-NC 心肌梗死］

● Journal of Molecular and Cellular Cardiology.（IF=5.763）.Wang S, et.al. (2022). Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair.［中山大学中山医学院&南方医科大学珠江医院 Ad-SIRT6 & Ad-GFP 血管钙化］

● Molecular Neurobiology. (IF=5.682). Zhou B, et.al. (2022). FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.［南昌大学第一附属医院 Ad-FUS & Ad-FUS-K510Q  肌萎缩侧索硬化症］

● Cell and Bioscience. (IF=9.584). Mao M, et.al. (2022). SENP6 induces microglial polarization and neuroinflammation through de-SUMOylation of Annexin-A1 after cerebral ischaemia–reperfusion injury. ［华中科技大学附属同济医院&郑州大学附属中心医院 Ad-SENP6 & Ad-vector 脑中风］

● Arterioscler Thromb Vasc Biol.（IF=10.514）. Ren X, et.al. (2022). Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein. ［中国医学科学院阜外医院 Ad-TPRG1-AS1 & Ad-MYH9 动脉粥样硬化性心血管］

● Pharmacol Res.(IF=10.334). Zhu S, et al. (2022). The miR-145-MMP1 axis is a critical regulator for imiquimod-induced cancer stemness and chemoresistance. ［吉林大学第一医院转化医学研究所 Ad-miR-145 & Ad-control 肿瘤干性］

● Acta Biomaterialia.（IF=10.633）. Wang F, et.al. (2022). Adipose-derived stem cells with miR-150-5p inhibition laden in hydroxyapatite/tricalcium phosphate ceramic powders promote osteogenesis via regulating Notch3 and activating FAK/ERK and RhoA. ［中国医科大学 Ad-miR-150-5p & Ad-NC 骨质疏松症］

● Molecular Cancer. (IF=41.444).Lei Liu，et.al.（2021）.KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1. ［山东大学Ad-KDM6A & Ad-GFP 膀胱癌］

● Signal Transduction and Targeted Therapy.（IF=38.104）.Suowen Xu, et.al.（2021）.The zinc fifinger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction.［中国科技大学 Ad-KLF2 & Ad-GFP 内皮功能障碍］

● Redox Biology .(IF=10.787).Yaqian Huang，et.al.（2021）.Endogenous SO2-dependent Smad3 redox modification controls vascular remodeling. [北京大学第一医院 Ad-AAT1 血管重塑]

● Theranostics.（IF=38.104）.Yan Jiang, et.al.（2021）. Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis. [复旦大学Ad-Jmjd3 & Ad-Jmjd3-mut肝纤维化]

● Nat Commun. (IF=17.694). Liu R, et.al. (2022). MicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake. ［山东第一医科大学附属眼科研究所Ad-GFP＆Ad-CMV-Glut2＆Ad-insulin 1-miR-21  胰腺β细胞］

● Cell Metab. (IF=27.287). Zhou N, et.al. (2022). Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses. ［北京大学&山一大附属省立医院 Ad-PPARd &Ad-OTUD3&Ad-control 糖脂代谢］

● Genes & Diseases. (IF=7.103). Luo J, et.al. (2022). PLSCR1 Promotes Apoptosis and Clearance of Retinal Ganglion Cells in Glaucoma Pathogenesis. ［中山大学Ad-PLSCR1&Ad-control 青光眼］

●  J Cell Physiol.  (IF=5.546) . Wang M, et al. (2021) . Lack of Mof reduces acute liver injury by enhancingtranscriptional activation of Igf1. [过表达/干扰 急性肝损伤]

●  Front Cell Dev Biol.  (IF=5.201) . Gu J, et al. (2021) . CFTR Deficiency Affects Glucose Homeostasis via Regulating GLUT4 Plasma Membrane Transportation. [过表达 成肌细胞]

●  Front Immunol.  (IF=5.085) . Wu L, et al. (2021) . EZH2 Inhibition Interferes With the Activation of Type I Interferon Signaling Pathway and Ameliorates Lupus Nephritis in NZB/NZW F1 Mice. [过表达 狼疮肾炎]

●  [4]Oxid Med Cell Longev.  (IF=5.076) . Gao Y, et al. (2021) .Rap1GAP Mediates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Inhibiting Autophagy and Increasing Oxidative Stress. [过表达 心肌]

●  J Cell Mol Med.  (IF=4.486) . Lei W，et al. (2021) . MARCH5 restores endothelial cell function against ischaemic/hypoxia injury via Akt/eNOS pathway. [过表达 心肌]

●  J Biol Chem.  (IF=4.238) . Zhang Z，et al. (2021) . The adaptor protein GIPC1 stabilizes the scavenger receptor SR-B1 and increases its cholesterol uptake. [过表达/干扰 肝脏]

●  J Anim Sci Biotechnol.  (IF=4.167) . Liu J, et al. (2021) . Comprehensive evaluation of the metabolic effects of porcine CRTC3 overexpression on subcutaneous adipocytes with metabolomic and transcriptomic analyses. [过表达 脂肪细胞]

●  Aging. (IF=4.831) .Chen Y, et al. (2020). Mitophagy impairment is involved in sevoflurane-induced cognitive dysfunction in aged rats[自噬双标 术后认知功能障碍].

● Elife Tool. (IF=7.08). Wu L, et al. (2019). PARIS, an optogenetic method for functionally mapping gap junctions.［北京大学 Ad-CMV-pHluorinCAAX 缝隙连接探针］

● Cell Death Dis. (IF=6.304). Su Y, et al. (2019). MicroRNA-181a-5p and microRNA-181a-3p cooperatively restrict vascular inflammation and atherosclerosis.［中山大学眼科中心 & 中山大学中山医学院 Ad-TAB2 & Ad-NEMO HUVECs 动脉粥样硬化］

● EBioMedicine. (IF=5.736). Wang K, et al. (2019). TGF-beta1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM.［温州医科大学附属台州医院 Ad-p65 & Ad-EV 肝纤维化］

● Arthritis Res Ther. (IF=4.103). Zeng J, et al. (2019). Interferon-alpha exacerbates neuropsychiatric phenotypes in lupus-prone mice.［上海交通大学医学院附属仁济医院 Adv-IFN-α & Adv-ctrl系统性红斑狼疮］

● Oncogene. (IF=7.971). Yu M, et al. (2018). Circadian regulator NR1D2 regulates glioblastoma cell proliferation and motility. ［北京大学深圳研究生院 Ad-AXL 胶质母细胞瘤］

● Cell Death Discov. (IF=4.114). Zhang SQ, et al. (2018). Oleanolic acid enhances neural stem cell migration, proliferation, and differentiation in vitro by inhibiting GSK3beta activity.［香港浸会大学 Ad-GSK3β (S9A) 神经干细胞NSCs］

● Int J Mol Med. (IF=3.098). Zhang L, et al. (2018). Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-kappaB pathway.［武汉大学人民医院张杰团队 Ad-Lefty-1 肾脏炎］

● Redox Biol. (IF=9.986). Jin Q, et al. (2018). DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways.［中国人民解放军总医院 Ad-DUSP1 & Ad-ctrl 心脏缺血再灌注损伤］

● Cell Physiol Biochem. (IF=5.5). Wang Y, et al. (2018). Inhibition of Histone Deacetylases Prevents Cardiac Remodeling After Myocardial Infarction by Restoring Autophagosome Processing in Cardiac Fibroblasts. ［浙江大学医学院附属第二医院Ad- mCherry-GFP-LC3 心脏重塑］

● Brain,Behavior,and Immunity. (IF=6.633). Zhou Y.T, et al. (2017). Interleukin-1βimpedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion.［浙江大学 Ad-IL-1R1-RFP & Ad-RFP 皮层下缺血性血管性痴呆SIVD］

● J Pharmacol Sci. (IF=2.835). Li J, et al. (2016). PKCζ interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy.［中山大学 Ad-PKCζ & Ad-GFP心肌肥厚］

● Arthritis Rheumatol. (IF=9.586). Han X, et al. (2016). MicroRNA-130b Ameliorates Murine Lupus Nephritis Through Targeting the Type I Interferon Pathway on Renal Mesangial Cells.［上海交通大学医学院 Ad-IFNα5 狼疮肾炎］

● Sci Rep. (IF=3.998). Zhang H, et al. (2016). Endogenous sulfur dioxide is a novel adipocyte-derived inflammatory inhibitor. entific Reports.［北京大学第一医院 Ad-AAT1 3T3-L1 cell 脂肪组织慢性炎症］

● Mol Cell Biol. (IF=3.611). Wu C, et al. (2016). Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity.［南方科技大学 Ad-Cre RNA聚合酶I转录活性］

● Pharmacol Res.（IF=10.334）. Dong Y, et.al. (2022). Blocking the cytohesin-2/ARF1 axis by SecinH3 ameliorates osteoclast-induced bone loss via attenuating JNK-mediated IRE1 endoribonuclease activity. ［华中科技大学附属同济医院 Ad-4in1-shCytohesin-1 ；Ad-4in1-shCytohesin-2；Ad-4in1-shCytohesin-3；Ad-4in1-shNC 骨质疏松］

● Mol Ther. (IF=12.910). Zheng H, et al. (2022) . CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output. ［南方医科大学 Ad-shcircSamd4 & Ad-NC 心肌梗死］

● Biomedicine & Pharmacotherapy.（IF=7.419）. Hong Q, et.al. (2022). Trimethylamine-N-oxide (TMAO) promotes balloon injury-induced neointimal hyperplasia via upregulating Beclin1 and impairing autophagic flux .［南方医科大学珠江医院 Ad-shBeclin1 & Ad-shNC 血管重塑］

● Journal of Cellular and Molecular Medicine. (IF=4.486). Wang, et al. (2020). Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss. ［华中科技大学同济医学院同济医院骨科 murine PFKFB3 Adenoviruses-4 in 1 shRNA-GFP 骨髓源性巨噬细胞BMMs MOI=50 破骨细胞相关疾病］

● EBioMedicine. (IF=5.736. Li, et al. (2019). Inhibition of AZIN2-sv induces neovascularization and improves prognosis after myocardial infarction by blocking ubiquitin-dependent talin1 degradation and activating the Akt pathway.［南方医科大学南方医院 AZIN2-sv Adenoviruses-4 in 1 shRNA-GFP 人脐静脉内皮细胞HUVECs MOI=100 新血管形成］

● Bone. (IF=4.147). Zhao, et al. (2018). YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism.［华中科技大学同济医学院同济医院骨科 murine YAP1 Adenoviruses-4 in 1 shRNA-GFP 骨髓源性巨噬细胞BMMs & RAW264.7 cells 破骨细胞生成］

● Cardiovascular Research. (IF=8.168. Li, et al. (2018). Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration.［南方医科大学南方医院 AZIN2-sv Adenoviruses-4 in 1 shRNA-GFP 心肌细胞CMs MOI=100 & 大鼠心肌注射 心脏再生］

● Br J Pharmacol. (IF=6.304). Ma Z.G, et al. (2016). Protection against cardiac hypertrophy by geniposide involves the GLP-1 receptor / AMPKalpha signalling pathway. ［武汉大学人民医院 Ad-shAMPKα2 心肌肥厚］

● Clin Sci . (IF=5.223). Ling Y, et al. (2016). Polydatin post-treatment alleviates myocardial ischaemia/reperfusion injury by promoting autophagic flux. ［南方医科大学珠江医院 Ad-sh-Beclin1&Ad-NC 心肌缺血再灌注损伤］

● Int J Biol Sci. (IF=4.858). Ma Z G, et al. (2016). Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKalpha Signalling Pathway. ［武汉大学人民医院 Ad-shAMPKα2 心肌肥厚］

● Nat Commun. (IF=12.121). Fu R, et al. (2020). Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis. ［中国药科大学Ad-βGal & Ad-Cre 骨质疏松］

● Cancer Sci. (IF=4.966). Wang X, et al. (2020). Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo. ［南方科技大学Ad-LacZ & Ad-Cre 肺癌］

● Int. J. Mol. Sci. (IF=4.556). Xu, et al. (2020). Effective MSTN Gene Knockout by AdV-Delivered CRISPR/Cas9 in Postnatal Chick Leg Muscle.［上海交通大学 AdV-CRISPR system(pAdM-U6-gRNA1-U6-gRNA2-CMV-spCas9) 鸡胚成纤维细胞DF-1 MOI=1000 & 鸡肌肉注射 鸡骨骼肌的生长和发育］

● ACS Nano.（IF=18.027）.ChunHua-Zhao，et.al.（2023）.Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer.［中山大学肿瘤防治中心、东海大学LV-EF1a-luciferase-CMV-GFP-P2A-Puro三阴性乳腺癌］

● Death and Disease，（IF 9.685）. Xie XF.（2023）. BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids.［中国医学科学院北京协和医学院，LV-BACH1、LV-shBACH1，食管鳞状细胞癌］

● Cancer Immunology, Immunotherapy，（IF 6.63）. Wu PT.（2023）. LILRB2-containing small extracellular vesicles from glioblastoma promote tumor progression by promoting the formation and expansion of myeloidderived suppressor cells［苏州大学第二附属医院&上海华山医院LV-pirb & LV-pirb-RFP & LV-nc 小鼠胶质母细胞瘤GL261细胞系 MOI=50， 胶质母细胞瘤］

● The Journal of Nutritional Biochemistry.（IF=5.6）.Chen H, et.al. (2023). Autophagy and exosomes coordinately mediate quercetin's protective effects on alcoholic liver disease.［华中科技大学 Lv-CYP2E1 酒精性肝病］

● Journal of Translational Medicine（IF=8.440）Bo Sun，et.al.（2023）.AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway.［湖南省人民医院 AFAP1L1/VAV2/ITGA5过表达以及干扰慢病毒 胃癌］

● Cell Death Discovery. (IF 7.0) Wang et.al. (2023). NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress. [湖北医药学院 NSUN2慢病毒过表达载体 心脏]

● Journal of Experimental & Clinical Cancer Research. (IF 12.658) Huang et.al. (2023). Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling. [中山大学孙逸仙纪念医院 LCN2慢病毒过表达和敲除载体 口腔鳞状细胞癌]

● Molecular Cell. (IF 19.328) Jinzhou Huang et.al. (2023). SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology. [同济大学医学院 53BP1慢病毒干扰过表达载体 DNA修复]

● CNS Neurosci Ther.（IF=7.035）. Miao Y，et.al. (2023). Anti-cancer effect of targeting fibroblast activation protein alpha in glioblastoma through remodeling macrophage phenotype and suppressing tumor progression.［首都医科大学附属北京天坛医院 Lv-FAP 胶质母细胞瘤］

●Oncogene.（IF=8.756）. Chen H，et.al. (2022). Extracellular vesicles-transferred SBSN drives glioma aggressiveness by activating NF-κB via ANXA1-dependent ubiquitination of NEMO.［广州医科大学 Lv-SBSN 胶质瘤］

●Cell Reports.（IF=9.995）. Li H, et.al. (2022). β-hydroxybutyrate reduces reinstatement of cocaine conditioned place preference through hippocampal CaMKII-a β-hydroxybutyrylation.［四川大学华西医院 pLenti-EF1α-CMV-CaMKII-α-Flag-GFP-2A-Puro；pLenti-EF1α-CMV-mutant CaMKII-α-Flag-GFP-2A-Puro 药物成瘾］

● Cancer Letters.（IF=9.756）.Wang Y , et.al. (2022). NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity.［浙江大学医学院 Lv-NNMT&Lv-NNMTY20 乳腺癌］

● J Exp Clin Cancer Res.（IF=12.658）. Qiu S, et.al. (2022). Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis.［南京医科大学第一附属医院 Lv-miR-519a-3p ；Lv-miR-519a-3p-shRNA 胃癌肝转移］

● Cancer Lett. (IF=9.756). Wang Y, et.al. (2022). NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity. ［浙江大学医学院 pLenti-Pur-NNMT & pLenti-Pur-NNMT-Y20 & pLenti-Pur 乳腺癌］

● EBioMedicine. (IF=11.205). Xiao RW, et.al. (2022). Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication. ［中山大学附属肿瘤医院 Lv-POLN 鼻咽癌］

● J Exp Clin Cancer Res. (IF=12.658). Qiu S, et.al. (2022). Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis. ［南京第一附属医院 Lv-miR-519a-3p&Lv-miR-519a-3p-shRNA 胃癌］

● Am J Med Sci. (IF=3.462). Luo R. (2022). CircRNA circ-MYBL2 absorbs precursor miR-92b in the nucleus to suppress its role in enhancing gastric cancer cell proliferation. ［成都人民医院 LV-circ-MYBL2 胃癌］

● Cancer Letters. (IF=9.756).Peng Nan, et.al.(2021).Tumor-stroma TGF-β1-THBS2 feedback circuit drives pancreatic ductal adenocarcinoma progression via integrin αvβ3/CD36-mediated activation of the MAPK pathway.［中国医学科学院北京协和医学院Lv-shPCK2-1 & Lv-shPCK2-2胰腺导管腺癌］

● Cancer Letters. (IF=9.756). Xiaofeng Li，et.al.(2021).SETD8 stabilized by USP17 epigenetically activates SREBP1 pathway to drive lipogenesis and oncogenesis of ccRCC.［山东大学齐鲁医院pLent-U6- SETD8-GFP-Puro 肾细胞癌］

● J Immunother Cancer.（IF=12.469）. Chao Liu,et.al.(2021).Blocking IL- 17A enhances tumor response to anti- PD- 1 immunotherapy in microsatellite stable colorectal cancer [哈尔滨医科大学肿瘤医院pLent-Puro- CMV- miR-15b-5p & AAV- miR- 15b- 5p 直肠癌 ]

● Cell Death & Disease. (IF=6.304). Liu, et al. (2020). Long noncoding RNA SNHG12 promotes tumour progression and sunitinib resistance by upregulating CDCA3 in renal cell carcinoma.［华中科技大学同济医学院附属协和医院pLent-SNHG12-GFP-Puro & pLent-shSNHG12-GFP-Puro 肾癌细胞RCC cells］

● Cell Death & Disease. (IF=6.304). Liu, et al. (2020). Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression.［香港浸会大学 lentivirus-CA-TLR4, fused with Myc and Flag tags 黑色素瘤细胞A375 cells］

● Cell Death & Disease. (IF=6.304). Wang, et al. (2019). LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.［华中科技大学同济医学院附属协和医院 pLent-LXRα-GFP-Puro & pLent-GFP-sh-LXRα-Puro 肾癌细胞RCC cells］

● Biochemical and Biophysical Research Communications. (IF=2.985). Zhu, et al. (2019). MicroRNA-506 inhibits the proliferation and invasion of mantle cell lymphoma cells by targeting B7H3.［北京大学第三医院 lent-miR-506 套细胞淋巴瘤细胞］

● Molecular Cancer. (IF=15.302). Tan, et al. (2019). PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA.［中山大学 pLent-Puro-GFP-piR-36712 人乳腺癌细胞MCF7和ZR75-1］

● Advanced Science. (IF=15.84). Lai, et al. (2018). A Modular Assembly of Spinal Cord–Like Tissue Allows T argeted Tissue Repair in the T ransected Spinal Cord. ［中山大学 pLent-EF1a-NT-3-Flag-CMV-GFP-P2A-Puro & pLent-EF1a-TrkC-Flag-CMV-GFP-P2A-Puro & pLent-EF1a-CNTF-Flag-CMV-GFP-P2A-Puro 神经干细胞NSCs & 少突胶质前体细胞OPCs 脊髓损伤］

● Theranostics. (IF=8.579). Mai, et al. (2018). PIWI-interacting RNA-54265 is oncogenic and a potential therapeutic target in colorectal adenocarcinoma.［中山大学 pLent-Puro-GFP-piR-54265 人结肠癌细胞HCT116和LoVo］

● Toxicology Letters. (IF= 3.569). Yan, et al. (2018). Inhibitory Effect of PXR on Ammonia-induced Hepatocyte Autophagy via P53.［福建医科大学附属协和医院 pLent-EF1a-PXR-CMV-GFP & pLent-U6-shPXR-GFP-Puro 人肝细胞HL-7702 和人肝癌细胞 BEL-7404 肝自噬］

● Metabolism Clinical and Experimental. (IF 13.934) Zhang et.al. (2022). ABCA1 deficiency-mediated glomerular cholesterol accumulation exacerbates glomerular endothelial injury and dysfunction in diabetic kidney disease. [四川大学华西医院 pLent-RFP-shRNA-ABCA1 慢病毒干扰载体 糖尿病]

● Journal of Agricultural and Food Chemistry.（IF=5.895）.Di-Ran，et.al.（2023）.Reactive Oxygen Species Control Osteoblast Apoptosis through SIRT1/PGC-1α/P53Lys382 Signaling, Mediating the Onset of Cd-Induced Osteoporosis.［扬州大学Lv-SIRT1-shRNA干扰慢病毒 骨质疏松］

● Cell Death & Differentiation.（IF=12.067）.Zhang G , et.al. (2023). Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.［四川大学华西第二医院、武汉大学 pLent-shCT55 雄性不育］

● Angiogenesis.(IF=10.658 ).Weisi-Lu，et.al.（2022）.PDGFD switches on stem cell endothelial commitment.［中山大学中山眼科医院 PDGFD过表达和敲低（4in1 shRNA）慢病毒载体 血管病干细胞治疗］

● Journal of Cachexia, Sarcopenia and Muscle.（IF=12.063）.You W , et.al. (2022). Growth arrest and DNA damage-inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha.［浙江大学动物科学学院 Lv-GADD45A-shRNA 肌内脂肪沉积］

● Neurosci Bull.（IF=5.271）.Wang T, et.al. (2022). The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse.［北京大学第六医院 LV-CRH-shRNA 睡眠障碍］

● Cancer Letters. (IF=9.756).Zongpan Jing, et.al.(2021).Acetylation-induced PCK isoenzyme transition promotes metabolic adaption of liver cancer to systemic therapy.[北京协和医科大学肿瘤医院 Lv-PCK2-shRNA 肝癌]

● Molecular Therapy: Nucleic Acids. (IF=10.183).Yu Zhang，et.al.(2021). Suppression of RNA editing by miR-17 inhibits the stemness of melanoma stem cells. [浙江大学 Lv-DOCK2-shRNA & psPAX & PMD2.G质粒 黑色素瘤干细胞]

● Cell Death and Disease. (IF=9.685).Xiaofang Chen，et.al.(2021). TCP1 increases drug resistance in acute myeloid leukemia by suppressing autophagy via activating AKT/mTOR signaling. [福建医科大学附属协和医院 Lv-TCP1-shRNA 急性髓系白血病]

● Cell Death and Disease. (IF=9.685). Bo Sun，et.al.(2021). Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation. [中南大学湘雅医院 Lv-PP2Ac-shRNA & Lv-PDCD10-shRNA 肝癌]

● Cancer Letters. (IF=9.756).Fang-Jing Zhong, et.al.(2021).STMN2 mediates nuclear translocation of Smad2/3 and enhances TGFβ signaling by destabilizing microtubules to promote epithelial-mesenchymal transition in hepatocellular carcinoma. [中南大学湘雅医院 STMN2 3保1-shRNA 肝癌]

● Bioact Mater. (IF=14.593). Liu Y, et.al. (2021). DNA aptamer S11e recognizes fibrosarcoma and acts as a tumor suppressor. ［湖南大学 Diablo/SMAC 3保1 shRNA慢病毒 纤维肉瘤］

● Cell Death & Disease. (IF=6.304). You, et al. (2020). GADD45α drives brown adipose tissue formation through upregulating PPARγ in mice.［浙江大学 Lenti-sh-Gadd45a BAT cell & Ad-Gadd45a SVF细胞 肥胖］

● Journal of Neuroinflammation. (IF=5.793). Zeng, et al. (2019). Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury.［北京大学第三医院 LV-SNCA-shRNA 脊髓损伤］

● Cell Discovery. (IF=6.255). Liao, et al. (2019). USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia.［广州医科大学 pLent-4in1shRNA(For USP10/SKP2)-GFP & pLent-EF1a-FH-CMV-GFP containing SKP2-CDS, SKP2 (S72A) CML cells MOI=10 慢性粒细胞白血病CML］

● International Journal of Biological Sciences. (IF=4.858). Zheng, et al. (2019). Cathelicidin-related antimicrobial peptide protects against cardiac fibrosis in diabetic mice heart by regulating endothelial-mesenchymal transition.［郑州大学附属第一医院lentiviruses-shAMPKa1 心肌注射 糖尿病性心肌病］

● Oncogene. (IF=7.971). Liao, et al. (2018). Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination.{广州医科大学 pLent-4in1shRNA[For human USP14 (NM-005151)]-GFP 人乳腺癌细胞 MOI=10 雄激素受体阳性乳腺癌}

● J Mol Cell Cardiol. (IF= 4.133). Li, et al. (2017). TCONS_00075467 modulates atrial electrical remodeling by sponging miR-328 to regulate CACNA1C.［山东大学千佛山医院 4in1shRNA慢病毒lenti-RNAi-TCONS_00075467 原代心肌细胞 心房颤动AF的电重构］

● International Journal of Molecular Sciences (IF=6.208). Yang D, et.al. (2023). Pharmacological T argeting of Bcl-2 Induces Caspase 3-Mediated  Cleavage of HDAC6 and Regulates the Autophagy Process in Colorectal Cancer.［重庆文理学院 Lv-mCherry-GFP-LC3B 结直肠癌］

●ISCIENCE（IF 6.107）.Li Xiao.et.al.（2023）. Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection［香港城市大学 AAV-hSyn-CCK2.3 听觉皮层，立体定位注射，神经-皮层可塑性］

●BMC Biology. (IF=7.364). Wang Z, et.al. (2023). Neural ensembles in the murine medial prefrontal cortex process distinct information during visual perceptual learning.［中国科学技术大学 AAV9-CaMKlla-GCaMP6f、AAV2/9-CaMKIIa-hM4Di-mCherry、AAV2/9-CaMKIIa-mCherry视知觉学习］

●The FASEB Journal. (IF 5.834). Yang et.al. (2023). Netrin-1 attenuates cerebral ischemia/reperfusion injury by limiting mitochondrial ROS and Ca2+ levels via activation of AKT phosphorylation and mitochondrial m- AAA protease AFG3L2. [上海交通大学医学院 Ad-Netrin-1；Ad-Control；Ad-shNetrin-1；Ad-shControl AAV-Netrin-1；AAV-Control；AAV-U6-shNetrin-1；AAV-U6-shControl  AAV腺病毒过表达和干扰载体 脑损伤]

●Phytomedicine. (IF 6.656) Ouyang et.al. (2023). Khellin as a selective monoamine oxidase B inhibitor ameliorated paclitaxel-induced peripheral neuropathy in mice. [南京中医药大学 AAV-MAOB-shRNA AAV干扰载体 神经]

●Lipocalin 2 in the Paraventricular Thalamic Nucleus Contributes to DSSInduced DepressiveLike Behaviors［浙江大学医学院邵逸夫医院AAV-CMV-shLcn2 丘脑室旁核（PVT），双侧注射 抑郁样行为］

●Biomaterials. (IF 15.304) Lai et.al. (2023). Tail nerve electrical stimulation promoted the efficiency of transplanted spinal cordlike tissue as a neuronal relay to repair the motor function of rats with transected spinal cord injury. [中山医学院 CNTF NT3 TrkC AAV过表达载体 神经]

●iScience（IF=6.107）.Mahadi Hasan，et.al.（2023）.Chemogenetic activation of astrocytes promotes remyelination and restores cognitive deficits in visceral hypersensitive rats.［香港城市大学 AAV8-GFAP-hM3D(Gq)-mCherry 认知缺陷］

●Translational Psychiatry（IF=7.989）.Ya-Xin Sun ，et.al.（2023）.The causal involvement of the BDNF-TrkB pathway in dentate gyrus in early-life stress-induced cognitive deficits in male mice.［北京大学第六医院 AAV2/9-CaMKIIa-Cre-P2A-GFP & AAV2/9-CaMKIIa-GFP 认知障碍］

●Neurosci. Bull.(IF=5.271).SiYue-Qin，et.al.（2022）.REEP1 Preserves Motor Function in SOD1G93A Mice by Improving Mitochondrial Function via Interaction with NDUFA4.［山东大学基础医学院AAV1-hREEP1-Flag & AAV1-GFP 神经退行性疾病］

●Neuron. (IF 18.688) Yang et.al. (2023). Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA. [约翰霍普金斯大学 Gabrd AAV敲除载体 神经]

● CELL MOL BIOL LETT. (IF 8.702) Zhonglin Cai et.al. (2022). ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood–testis barrier integrity. [中国医学科学院北京协和医院 ALKBH5 AAV干扰载体 血睾屏障]

● Cell Reports.（IF=9.995）. Li H, et.al. (2022). β-hydroxybutyrate reduces reinstatement of cocaine conditioned place preference through hippocampal CaMKII-a β-hydroxybutyrylation.［四川大学华西医院 AAV2/9-CaMKII-α-EGFP-Flag；AAV2/9-mutant CaMKII-α-EGFP-Flag  药物成瘾］

● NEURAL REGENERATION RESEARCH.（IF=6.058）.Shu Liu，et.al.（2022）.Knockdown of NADPH oxidase 4 reduces mitochondrial oxidative stress and neuronal pyroptosis following intracerebral hemorrhage［南方医科大学珠江医院 AAV9-shRNA-NOX4 和AAV9-CON  脑出血治疗靶点］

● BMC biology.（IF=7.364）.Shu Liu，et.al.（2022）.Astrocytes in CA1 modulate schema establishment in the hippocampal-cortical neuron network.［香港城市大学AAV2/9-Ef1α-DIO-jGCaMp7s和AAV9-Syn-jGCaMp7s  CA1星形胶质细胞］

● Nat Biotechnol. （IF=68.164）.Qian T, et.al. (2023). A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments.［北京大学 AAV2/9-hSyn-OT1.0 ；AAV2/9-hSyn-OTmut；AAV2/9-hSyn-iGluSnFR (SF.iGluSnFR.A184V)；AAV2/9-CMV-BFP2-P2A-TeNT；AAV2/9-hSyn-DIO-PSD95-EGFP  催产素神经递质］

● Neuron（IF=18.688）.Tian F, et.al.(2022).Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells. ［哈佛医学院 小鼠gRNA AAV载体库 神经退行性疾病］

● Cell Reports.（IF=9.995）. Zhong C, et.al. (2022). A neural circuit from the dorsal CA3 to the dorsomedial hypothalamus mediates balance between risk exploration and defense. ［中国科学院深圳先进技术研究院 AAV9-CaMKII-eArchT-EYFP&AAV9-Ef1a-DIO-eArch3.0-EYFP 危险探索-防御行为］

● Journal of Neuroinflammation.（IF=9.578）.Fröhlich A, et.al. (2022). Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury. ［乌尔姆大学 AAV9-hSyn-TNFRSF11b-P2A-mCherry 创伤性脑损伤］

● Cell Rep.（IF=9.995）. Qi X, et.al. (2022). A nociceptive neuronal ensemble in the dorsomedial prefrontal cortex underlies pain chronicity. ［北京大学 AAV2/9-TRE3G-mCherry；AAV2/9-TRE3G-hM3DGq-mCherry 慢性疼痛］

● Nature. （IF=69.504）.Breton-Provencher, V. et al. (2022). Spatiotemporal dynamics of noradrenaline during learned behaviour. ［麻省理工学院 AAV9-hSyn-DIO-GRABNE2m 习得行为］

● Neurobiology of Stress.（IF=7.142）.Zhou H, et al. (2022). The antidepressant effect of nucleus accumbens deep brain stimulation is mediated by parvalbumin-positive interneurons in the dorsal dentate gyrus. ［华中科技大学同济医学院 AAV-EF1a-DIO-hM3Dq-mCherry & AAV-EF1a-DIO-hM4Di-mCherry 抑郁症］

● CNS Neurosci Ther.（IF=7.035）.Yun Y, et al. (2022). Targeting upregulated RNA binding protein RCAN1.1: a promising strategy for neuroprotection in acute ischemic stroke. ［山东大学齐鲁医院 AAV9-R1SR13 & AAV9-R-CON；Lenti-RCAN1.1L-GFP & Lenti-siRCAN1.1-GFP & Lenti-R1SR13-GFP & Lenti-CON 急性缺血性卒中］

● Neuron.（IF=18.688）. Chi S, et.al. (2022). Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions. ［清华大学 AAV2/9-GfaABC1D-ATP1.0 神经再生和认知］

● Cell Rep. （IF=9.995）.Dai B, et.al. (2022). Responses and functions of dopamine in nucleus accumbens core during social behaviors. ［纽约大学AAV9-hSyn-DIO-GRAB DA2m & AAV9-hSyn-loxP-GRAB DA2m -loxP 社会行为］

● Neurosci Bull.（IF=5.271）. Wang T, et.al. (2022). The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse.［北京大学第六医院 AAV2/9-CAG-DIO-CRH-P2A-GFP 睡眠障碍］

● Mol Neurobiol.（IF=5.682）. Chen B, et.al. (2022). Celsr3 Inactivation in the Brainstem Impairs Rubrospinal Tract Development and Mouse Behaviors in Motor Coordination and Mechanic-Induced Response. ［暨南大学 AAV9-CMV-GFP&scAAV1-hSyn-Cre 脊髓损伤］

● Neuropharmacology.（IF=5.273）. Wang T, et.al. (2022). Malfunction of astrocyte and cholinergic inputs is involved in postoperative impairment of hippocampal synaptic plasticity and cognitive function.［徐州医科大学 AAV-hSyn-GACh3.0 术后谵妄］

● Signal Transduction and Targeted Therapy.（IF=38.104）.Ling Zhang, et.al.（2021）.SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration.［中国医学科学院北京协和医学院 AAV2-CMV-GFP & AAV9-CMV-GFP 血脑屏障］

● Nat Microbiol.（IF=30.964）.Boqiang Sun, et.al.（2021）.Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus-1 latency.［浙江大学 AAV-CAG-Foxc1神经元］

● NATURE COMMUNICATIONS.（IF=17.694）.Qian Wang, et.al.（2021）.Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice ［南方医科大学AAV8-GFAP-hM3Dq-mCherry and AAV9-GfaABC1D-ATP1.0 自闭症］

● Molecular Neurodegeneration.（IF=18.879）.Melanie Barth, et.al.（2021） Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures［德国神经退行性疾病中心 AAV-hA53T-αS 小胶质细胞］

● Protein Cell.（IF=15.328）.Xiaoyan Xu, et.al.（2021）. Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model［浙江大学 AAV-CAG-Hsc70-WT & AAV-CAG-Hsc70 S85A阿尔兹海默症］

● Cell Reports.（IF=9.995）. Zhuo Chen，et.al.（2021）. Deficiency of ER Ca²⁺ sensor STIM1 in AgRP neurons confers protection against dietary obesity.［华中科技大学AAV-EF1a-DIO-EGFP AgRP神经元内质网Ca²⁺传感器］

● MOL THER-NUCL ACIDS. (IF=8.886). Qianqian Cao, et.al. (2022). Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson’s disease-like pathology.［暨南大学 AAV9-hSyn-human SNCA 帕金森病］

● J Neuroinflammation. (IF=8.322). Huo S, et.al. (2021). Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice. ［南开大学 AAV9-CaMKIIα-TRPC5 & AAV9-GFP 记忆障碍］

● Nature Neuroscience. (IF=20.071). Zhang, G.W., et al. (2021). Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior. ［南加州大学 AAVretro-Cre 神经元逆行标记 焦虑与父母行为］

● Nature Communications. (IF=12.121). Xu, et.al. (2020). CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis.［中国科学院昆明动物所 AAV9-shRNA(circGRIA1) & AAV9-shRNA(control) 灵长类动物恒河猴脑衰老］

● Science Advances. (IF=13.116). Sun, et.al. (2020). Development of a CRISPR-SaCas9 system for projection- and function-specific gene editing in the rat brain.［北京大学 CRISPR-saCas9 基因编辑雄性SD大鼠特定神经元群］

● The Journal of Neuroscience. (IF=5.673). Zingg B, et.al. (2020). Synaptic Specificity and Application of Anterograde Transsynaptic AAV for Probing Neural Circuitry.［南加利福尼亚大学scAAV1 hSyn-Cre & AAV1-hSyn-Flp & AAVretro-hSyn-Cre & AAV1-EF1a-DIO-Flp-WPRE & AAVretro-hSyn-GFP-WPRE 顺向跨单级突触示踪］

● Molecular Psychiatry. (IF=12.384). li, et.al. (2020). Programmed cell death 4 as an endogenous suppressor of BDNF translation is involved in stress-induced depression.［山东大学 AAV9-CMV-mPdcd4-P2A-GFP 抑郁症］

● Biological Psychiatry. (IF=12.095). Zhang, et.al. (2020). Reduced neuronal cAMP in the nucleus accumbens damages blood-brain barrier integrity and promotes stress vulnerability.［中国药科大学 Dox 诱导性AAV2/9-shRNA-Adcy5 or AAV2/9-shRNA 抑郁症］

● Cell Reports. (IF=8.109). Ma, et.al. (2019). Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation. ［北京大学 AAV2 retro-hSyn-Cre-GFP & AAV2-CAG-DIO-BDNF-mCherry-3*flag 慢性疼痛］

● Cell. (IF=38.637). Fan, et.al. (2019). Stress-Induced Metabolic Disorder in Peripheral CD4+T Cells Leads to Anxiety-like Behavior. ［浙江大学 AAV9-GFAP-GFP-miR30-shRNA(mAdora1) & AAV8-MBP-GFP-miR30-shRNA(mAdora1) & AAV8-MBP-GFP-miR30-shRNA(scramble) 焦虑精神疾病］

● Neuron. (IF=14.415). Feng, et.al. (2019). A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine.［北京大学AAV9-hSyn-NE1m & NE1h and AAV9-hsyn-tTA 去甲肾上腺素神经递质探针］

● Cell. (IF=38.637). Sun, et.al. (2018). A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies,Fish, and Mice.［北京大学AAV-hSyn-DA1m & DA1h 多巴胺神经递质探针］

● Behavioural Neurology. (IF=2.093). Qu, et.al. (2018). MST1 Suppression Reduces Early Brain Injury by Inhibiting the NF-κB/MMP-9 Pathway after Subarachnoid Hemorrhage in Mice.［第三军医大学西南医院神经外科 MST1 AAV-4 in 1 shRNA-GFP 脑室注射 蛛网膜下腔出血］

● Neuron. (IF=14.415). Zingg B, et.al. (2017). AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors.［南加利福尼亚大学AAV1-EF1a-DIO-Flp 顺向跨单级突触示踪］

● Journal of Molecular Medicine，（IF 5.606）. Shao SY.（2023）. Never in mitosis gene Arelated kinase6 deficiency deterioratesdiabetic cardiomyopathy via regulating heat shock protein 72.［郑州大学第一附属医院Ad-NEK6，MOI=50，心肌细胞，糖尿病心肌病］

● Journal of Molecular Medicine. (IF=5.606). Wu L, et.al. (2023). TRIM-containing 44 aggravates cardiac hypertrophy via TLR4/NOX4-induced ferroptosis.［郑州大学第一附属医院AAV9-cTnT-TRIM44、AAV9-cTnT-shTRIM44 心肌肥厚］

● Oxidative Medicine and Cellular Longevity. (IF=7.310). Li WJ, et.al. (2023). Cryptotanshinone Attenuated Pathological Cardiac Remodeling In Vivo and In Vitro Experiments. ［武汉大学人民医院AAV9-STAT3 & AAV9-GFP 心脏重塑］

● Cell Reports. (IF=8.8). Zou J, et.al. (2023). Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation. ［奥古斯塔大学AAV9-cTnT-Cre-WPRE 心脏成熟］

● Cells. (IF=7.666) Fangfang Li et.al. (2022). KLF9 Aggravates Streptozotocin-Induced Diabetic Cardiomyopathy by Inhibiting PPARγ/NRF2 Signalling. [徐州医科大学附属医院 KLF9 AAV过表达和干扰载体 糖尿病性心肌病]

● cells.（IF=7.666）. Chen Z, et.al. (2022). TMEM43 Protects against Sepsis-Induced Cardiac Injury via Inhibiting Ferroptosis in Mice. ［华中科技大学同济医学院武汉中心医院 AAV9-cTNT-TMEM43；AAV9-cTNT-shTMEM43 脓毒症性心肌病］

● Sci Adv. (IF=14.136). Bi HL, et.al. (2022). The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor. ［大连医科大学附属医院 rAAV9-CMV-UCHL1 & rAAV9-CMV-GFP 心肌肥厚］

● ACTA PHARM SIN B. （IF=14.903）. Wu X, et al. (2022). Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS. ［中国药科大学 AAV9-cTnT-shPKM2 & AAV9-cTnT-wildtype PKM2 & AAV9-cTnT-mutants PKM2 心肌缺血］

● Mol Ther. (IF=12.910). Zheng H, et al. (2022) . CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output. ［南方医科大学 AAV9-circSamd4&AAV9-NC 心肌梗死］

● FRONT CARDIOVASC MED. (IF=7.419).Xin Huang , et.al. (2021). Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson’s disease-like pathology.［首都医科大学 AAV9-Sfrp5心肌梗死］

● MOL THER-NUCL ACIDS. (IF=8.886). Xiang He, et.al. (2021). CircRNA Chordc1 protects mice from abdominal aortic aneurysm by contributing to the phenotype and growth of vascular smooth muscle cells. ［南方医科大学南方医院 AAV9-circChordc1-shRNA & AAV9-Scr 腹主动脉瘤］

● Theranostics. (IF=11.556). Hao Li, et.al. (2021). Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)–induced dissecting abdominal aortic aneurysm . ［中国医学科学院阜外医院 AAV9-LH1-P2A-GFP & AAV9-GFP 腹主动脉瘤］

● J Mol Med (Berl). (IF=4.599). Li F, et.al. (2021). Zinc finger and BTB domain-containing protein 20 aggravates angiotensin II-induced cardiac remodeling via the EGFR-AKT pathway. ［徐州医科大学附属医院 AAV9-ZBTB20 & AAV9-shZBTB20 心脏重构］

● Hypertension. (IF=7.713). Liu, Wen, Li, et.al. (2020). Oleic Acid Attenuates Ang II（Angiotensin II）-Induced Cardiac Remodeling by Inhibiting FGF23（Fibroblast Growth Factor 23.［中国医学科学院阜外医院 AAV9-Fgf23&AAV9-GFP 高血压心脏重构］

● International Journal of Molecular Medicine. (IF=3.098). Huang, et.al. (2019). Redd1 protects against post-infarction cardiac dysfunction by targeting apoptosis and autophagy.［华中科技大学同济医学院附属协和医院 AAV9-Redd1 & AAV9-GFP 心肌梗死MI］

● Frontiers in Pharmacology. (IF=4.225). Shen, et.al. (2019). Downregulation of miR-146a Contributes to Cardiac Dysfunction Induced by the Tyrosine Kinase Inhibitor Sunitinib.［河北医科大学 AAV9-cTNT-GFP-miR-146a & AV-miR-146a SNT-诱导的心脏收缩障碍］

● Journal of Molecular and Cellular Cardiology. (IF=4.133). Wu, et.al. (2019). The protective effect of high mobility group protein HMGA2 in pressure overload-induced cardiac remodeling.［武汉大学 AAVs & Ads心脏重构］

● Biochemical and Biophysical Research Communications. (IF=2.985). Yang, et.al. (2018). Vaspin alleviates myocardial ischaemia/reperfusion injury via activating autophagic flux and restoring lysosomal function.［山东大学齐鲁医院 AAV-vaspin & Ad-RFP-GFP-LC3 心脏］

● Autophagy. (IF=13.391). Chen Z, et.al. (2022). Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-mediated autophagy. ［中国医学科学院阜外医院 rAAV8-HCRApoE/hAAT-D377Y-mPCSK9 动脉粥样硬化］

● Theranostics. (IF=11.600) .Hao Li, et.al.（2021）. Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)–induced dissecting abdominal aortic aneurysm. [北京协和医科大学AAV9-LH1&AAV9-GFP 腹主动脉瘤]

● Molecular Therapy: Nucleic Acids. (IF=10.183).Xiang He，et.al.(2021). CircRNA Chordc1 protects mice from abdominal aortic aneurysm by contributing to the phenotype and growth of vascular smooth muscle cells. [南方医科大学 AAV-circChrodc1-shRNA 腹主动脉瘤]

● Biomed Pharmacother. (IF=6.529). Wu Y, et.al. (2022). Endothelium-targeted delivery of PPARδ by adeno-associated virus serotype 1 ameliorates vascular injury induced by hindlimb ischemia in obese mice. ［香港中文大学 AAV-Vector & AAV-ICAM2-Ppard 下肢缺血］

● J ADV RES. (IF=10.479). Chak Kwong Cheng, et.al. (2022). SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis. ［香港中文大学 AAV-Vector & AAV-ICAM2-SOX4 动脉粥样硬化］

● Arteriosclerosis, Thrombosis, and Vascular Biology. (IF=6.604). Zhao, et.al. (2019). ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension.［山东大学齐鲁医院 AAV2-SM22α-ALDH2 & AAV1-ICAM2-ALDH2 低氧性肺动脉高压HPH］

● Journal of Molecular and Cellular Cardiology. (IF=4.133). Sun, et.al. (2019). LncRNA H19 promotes vascular inflammation and abdominal aortic aneurysm formation by functioning as a competing endogenous RNA.［南方医科大学南方医院 AAV9-H19 腹主动脉瘤AAA］

● Journal of Cerebral Blood Flow & Metabolism. (IF=5.681). Li, et.al. (2019). Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice.［中国医学科学院阜外医院 AAV9-LH3-p2A-GFP 高血压性脑出血ICH］

● Arteriosclerosis, Thrombosis, and Vascular Biology. (IF=6.604). Zhong, et.al. (2019). SM22α (Smooth Muscle 22α) Prevents Aortic Aneurysm Formation by Inhibiting Smooth Muscle Cell Phenotypic Switching Through Suppressing Reactive Oxygen Species/NF-κB (Nuclear Factor-κB).［南方医科大学南方医院 AAV9-SM22α 腹主动脉瘤AAA］

●Molecular Therapy: Nucleic Acid（IF 8.8）. Yang XS.（2023）.PPM1H is down-regulated by ATF6 and dephosphorylates p-RPS6KB1 to inhibit 1 progression of hepatocellular carcinoma［中国医学科学院 AAV8-PPM1H，AAV8-control 尾静脉注射，肝脏］

● Acta Pharmaceutica Sinica B. (IF 14.903). Zhu et.al. (2023). The E3 ubiquitin ligase NEDD4-1 protects against acetaminopheninduced liver injury by targeting VDAC1 for degradation. [吉林大学动物医学院 AAV过表达和干扰载体 肝脏]

● Nature Communications. (IF 17.694) Xiao et.al. (2023). Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice. [复旦大学脑科学转化研究院 PREP AAV过表达载体 肝脏和脂肪产热］

● Cell Biol Toxicol（IF=6.819）.Chen X, et.al. (2022). Activation of cDCs and iNKT cells contributes to triptolide-induced hepatotoxicity via STING signaling pathway and endoplasmic reticulum stress. ［中国药科大学AAV8-siSTING & AAV8-control 肝毒性］

● Metabolism（IF=13.934）.Yan H, et.al. (2022). FAM3A maintains metabolic homeostasis by interacting with F1-ATP synthase to regulate the activity and assembly of ATP Synthase.［北京大学医学部基础医学院AAV8-U6-shFOXD3 &AAV8-U6-GFP（pAV-3in1-shRNA-GFP ）  代谢性疾病］

● Hepatology. (IF=17.298). Wang T, et.al. (2022). Cellular heterogeneity and transcriptomic profiles during intrahepatic cholangiocarcinoma initiation and progression. ［华中科技大学同济医学院&西安交通大学 AAV8-CRISPR/sgZmiz1 &AAV8-CRISPR/sgYbx1 肝内胆管细胞癌］

● Cell Metabolism.(IF=31.373) . Lin Wang, et.al.（2021）. Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1.［第四军医大学西京医院肝胆外科 AAV8-TRIM16 & AAV8-GFP 非酒精性脂肪性肝炎］

● Cell Metab. (IF=27.287). Wang L, et.al. (2021). Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1. ［第四军医大学西京医院 AAV8-CMV-TRIM16&AAV8-CMV-GFP 非酒精性脂肪性肝炎］

● Hum Cell. (IF=4.174). Chen S, et.al. (2021). Overexpression of ring finger protein 20 inhibits the progression of liver fibrosis via mediation of histone H2B lysine 120 ubiquitination. ［杭州医学院附属人民医院 AAV8-TBG-RNF20 肝纤维化］

● Proc. Natl. Acad. Sci. U.S.A. (PNAS). (IF=9.412). Zhang, et.al. (2020). Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation.［中国人民解放军军事医学科学院 & 南开大学 AAV-DJ-CAG-Cre II型戊二酸尿症GA-II］

● Journal of Hepatology. (IF=20.582). She, et.al. (2019). PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target.［北京大学基础医学院 AAV8-hPSMP & null 肝纤维化］

● Theranostics. (IF=8.579). Liu, et.al. (2019). Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration.［浙江大学 AAV9-CMV-YAP 肝再生］

● Molecular Cell. (IF=15.584). Wan, et.al. (2019). Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.［浙江大学 AAV9-mCherry-GFP-LC3 and AAV9-Pacerwt-HA&Pacer2KR-HA&PacerS157A-HA&PacerS157D-HA 肝自噬和脂代谢］

● Experimental Cell Research. (IF=3.383). Li, et.al. (2018). Brg1 promotes liver fibrosis via activation of hepatic stellate cells.［华中科技大学同济医学院附属同济医院 AAV8-shBrg1 or AAV8-GFP 肝纤维化］

● Molecular Cell. (IF=15.584). Wan, et.al. (2018). mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.［浙江大学 AAV9-shHUWE1 & shNC and AAV9-WIPI2&WIPI2-S395A&WIPI2-S395D 肝自噬］

● Molecular Cell. (IF=15.584). Su, et.al. (2017). VPS34 Acetylation Controls Its Lipid Kinase Activity and the Initiation of Canonical and Non-canonical Autophagy.［浙江大学 AAV9-CMV-VPS34&3KR&3KQ 肝自噬］

● Proc. Natl. Acad. Sci. U.S.A. (PNAS). (IF=9.412). He, et.al. (2017). MicroRNA-351 promotes schistosomiasis-induced hepatic fibrosis by targeting the vitamin D receptor.［第二军医大学 AAV8-CMV-eGFP-miR-351-5p Sponge 血吸虫病肝纤维化］

● MOLECULAR THERAPY.（IF=12.910）. Nan Y, et.al. (2022). HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit apoptosis by activating c-Myc transcriptional activity.［中国医学科学院肿瘤医院 AAV-shHCP5 & AAV-shCtrl 食管鳞癌］

● ISCIENCE. (IF 6.107). Guo et.al. (2023). Steroidogenic factor 1 protects mice from obesity-induced glucose intolerance via improving glucose-stimulated insulin secretion by beta cells. [中山大学附属第一医院 AAV和腺病毒过表达载体 胰腺]

● Digestive Diseases and Sciences .（IF=3.487）.XiaoYu Yang，et.al.（2021）.MiR155 Disrupts the Intestinal Barrier by Inducing Intestinal Inflammation and Altering the Intestinal Microecology in Severe Acute Pancreatitis.［南昌大学第一附属医院AAV9-miR155和AAV9-miR155 sponge胰腺炎］

● Nature Communications（IF17.694）.Cheng R, et.al. (2023). Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity.［中国药科大学&东南大学AAV8-MIP (mouse insulin1 promoter)-circGlis3 糖尿病］

● Cell Research.（IF=46.297）.Cheng R, et.al. (2022). A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers.［中山大学第一附院&苏州大学&南京大学AAV9-shRNA-RASON&AAV9-shRNA-NC  KRAS突变癌］

● Clinical Cancer Research. (IF13.801). Ding et.al. (2023). A Tumor-suppressive Molecular Axis EP300/circRERE/ miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer. [厦门大学第一附属医院 AAV-CMV-circRNA-mCMV-copGFP AAV过表达载体 癌症]

● J Immunother Cancer .（IF=12.461）.Chao Liu，et.al.（2021）.Blocking IL- 17A enhances tumor response to anti- PD-1 immunotherapy in microsatellite stable colorectal cancer.［哈尔滨医科大学附属肿瘤医院AAV-miR-15b-5p sponge结直肠癌］

● Cancer Lett.（IF=9.756）.SiMiao Qiao，et.al.（2020）.Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer.［中国药科大学AAV9-CPT1 & AAV9-control结直肠炎］

● Nature Communications. (IF 17.694). Zhong et.al. (2023). Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice. [中山大学附属第六医院 AAV8-TAK1；AAV8-Vec；AAV8-Adipoq-Cre AAV过表达载体肥胖代谢]

● Acta Pharmaceutica Sinica B.（IF=14.5）.Tang WZ，et.al.（2023）.Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice.［南方科技大学&南方科技大学第一附属医院 AAV-Rec2-CasRx-sgRNA-Kindlin-2 脂肪］

● Protein & Cell.（IF=15.328）.Maomao-Pu，et.al.（2023）.ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover .［浙江大学医学院 AAV9-ORP8-WT 、AAV9-ORP8-T54A/S65A、AAV9-ORP8-LIRs-6A 、AAV9- ORP5 脂滴自噬］

● Free Radical Biology and Medicine.（IF=8.101）.Kai Sun，et.al.（2023）.JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.［华中科技大学同济医学院附属同济医院关节腔内注射AAV9-NCOA4 & AAV9-GFP骨关节炎治疗］

● Cell Reports.（IF=9.995）. Liu, et.al. (2022). Template-independent genome editing in the Pcdh15 av-3j mouse, a model of human DFNB23 nonsyndromic deafness.［清华大学 AAV2/9-mCherry&AAV2/9-m-3j-gRNA1 遗传性耳聋］

● Antioxidants(IF7.675).ZhangF,et.al.(2023).Melatonin Alleviates Retinal Ischemia-Reperfusion Injury by Inhibiting p53–Mediated Ferroptosis.［中山大学中山眼科中心 AAV2-p53& AAV2-GFP 视网膜缺血再灌注］

● COMPUT STRUCT BIOTEC（IF 6.155）. Zhang J, et.al. (2023). PDGF-D-induced immunoproteasome activation and cell-cell interactions.［中山大学中山眼科中心&广医-广州生物院 AAV-VMD2-PDGF-D&AAV-GFP 脉络膜新生血管］

● International Journal of Biological Sciences. (IF=4.858). Wu, et.al. (2019). Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.［温州医科大学附属第二医院 AAV9-U6-shRNA (Prkaa1)-CMV-EGFP 随意皮瓣］

● Life Sciences（IF=6.780）. Hu BC, et.al. (2023). Auto- and paracrine rewiring of NIX-mediated mitophagy by insulin-like growth factor-binding protein 7 in septic AKI escalates inflammation-coupling tubular damage.［浙江省人民医院AAV9-KSP1.3-miR30-sh.NIX &AAV9-sh.scr 脓毒性AKI］

● Nature Communications (IF=17.694). Yang Y, et.al. (2023). DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice.［南京医科大学附属儿童医院AAV8-U6-gRNA-DNA-PKcs；AAV8-U6-gRNA 慢性肾脏病］

● Molecular Therapy. （IF=12.910）. Ouyang X, et.al. (2022). A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating AKT/mTOR-autophagy pathway. ［广东人民医院 AAV9-sh-circ-ZNF609 & AAV9-ZNF609-250 & AAV9-sh-NC 急性肾损伤］

● Cytokine.(IF=3.926). Xu H, Wang Z. (2022). MicroRNA-23a-3p ameliorates acute kidney injury by targeting FKBP5 and NF-κB signaling in sepsis.［江西省人民医院 AAV2-miR-23a-3p 脓毒症急性肾损伤］

● Molecular Therapy. (IF=12.910) . Sung-Ah Hong, et.al.（2021）. In vivo gene editing via homology-independent targeted integration for adrenoleukodystrophy treatment. [延世大学AAV9-HITI & AAV9-SaCas9-sgRNA & AAV9-EGFP 肾上腺脑白质营养不良(ALD)]

● Acta Pharm Sin B. (IF=11.413). Jing X, et.al. (2021). Gene deficiency or pharmacological inhibition of PDCD4-mediated FGR signaling protects against acute kidney injury. ［山东大学 rAAV9-Fgr-GFP & rAAV9-GFP 急性肾损伤］

● J Pharmacol Sci. (IF=3.337). Zhou J, et.al. (2021). Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499-5p/APC axis. ［南京中医药大学附属医院 AAV9-miR-499-5p & AAV9-APC 糖尿病肾病］

● EBIOMEDICINE. (IF=5.736). Liu, et.al. (2019). H19 promote calcium oxalate nephrocalcinosis-induced renal tubular epithelial cell injury via a ceRNA pathway.［华中科技大学同济医学院附属同济医院 AAV9-H19 肾钙质沉着症］

● Science Translational Medicine. (IF=16.304). Wang, et.al. (2018). Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway.［南方医科大学 AAV9-MIR-GFP-lnc-TSI 肾纤维化］

● Cell Death & Disease. (IF=6.304). Zhang, et.al. (2019). circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA.［上海市第一人民医院 AAV6-circHIPK3 shRNA & scrambled shRNA 肺纤维化］

● Oncotarget. Tian, et.al. (2017). Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling.［华中科技大学同济医学院公共卫生学院 AAV-Sirt6 特发性肺纤维化］

● Retrovirology. (IF=4.183). Wang, et.al. (2017). Genome modifcation of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection.［武汉大学基础医学院 AAV-SaCas9-CXCR4-gRNA HIV基因治疗］

● Cell Metab. (IF=27.287). Loft Anne, et.al. (2022). A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis.［德国慕尼黑赫尔姆霍茨中心&乌尔姆大学 AAV-LP1-Cre & AAV-LP1-Cremut 肝脏禁食与生酮反应］

● EBioMedicine. (IF=8.143). Song Haoyu, Xu Tong, Feng Xiaofei, et.al. (2020). Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2.［南方医科大学&暨南大学附属珠海医院 AAV2-Irg1-GFP & AAV2-Nrf2-GFP& AAV2-Keap1-GFP 腹主动脉瘤AAA］

● EBioMedicine. (IF=5.736). Lian, et.al. (2019). Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway. ［北京大学 AAV2-ADAM17-GFP & AAV2-GFP 主动脉夹层AD］

● Circulation Research. (IF=14.467). Fu, et.al. (2016). Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Defciency Drives Atherosclerotic Calcifcation. ［北京大学 AAV2-integrin β3 & AAV2-β-tail domain & AAV2-GFP 动脉粥样硬化AS］

● CLINICAL CANCER RESEARCH（IF=13.801）.Zhang Y, et.al. (2023). Allogeneic CAR T Cells Targeting DLL3 Are Efficacious and Safe in Preclinical Models of Small Cell Lung Cancer.［Allogene公司 AAV-IL7 & AAV-IL15 小细胞肺癌］

● Mol Ther. (IF=12.910). Duan Y, et.al. (2022). Balancing activation and costimulation of CAR tunes signaling dynamics and enhances therapeutic potency. ［浙江大学医学院AAV-TRAC-1928z-WT & AAV-TRAC-1928z-1XX CAR-T细胞制备］

● Small Methods. (IF=15.367).Ruirui Jing，et.al.（2021）.Cas9-Cleavage Sequences in Size-Reduced Plasmids Enhance Nonviral Genome Targeting of CARs in Primary Human T Cells ［浙江大学AAV-TRAC-CAR-T ］

● Molecular Cell.(IF=17.970).Ling, et.al.(2021). Improving the efficiency of CRISPR-Cas12a-based genome editing with site-specific covalent Cas12a-crRNA conjugates.［北京大学AAV6-CD19 CAR CAR-T细胞制备］

生殖方面：

● Cell Reports Medicine.（IF=16.988）. Xia K, et.al. (2022). AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failure.［中山大学&中山大学附属第一医院 AAV-Lhcgr 雄性不育］

● Molecular Therapy: Nucleic Acid（IF=10.183）.Iancu O, et.al. (2022). Multiplex HDR for Disease and Correction Modeling of SCID by CRISPR Genome Editing in Human HSPCs.［巴伊兰大学  AAV6病毒产品 严重联合免疫缺陷］

●BMC Biology（IF=7.364）. Ying Z, et.al. (2022). CCHCR1-astrin interaction promotes centriole duplication through recruitment of CEP72.［深圳大学 HCR-KO HeLa细胞系 中心体组装］

●Cellular & Molecular Immunology. (IF 22.096). Lv et.al. (2023). Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells. [吉林大学第一医院表达ICOSL的细胞系 免疫]