AAV可在心脏组织有效、持久、稳定、安全地表达外源基因,因而在心脏基因治疗策略中占据独特优势。在使用rAAV进行心脏研究时,正确选择AAV血清型、启动子以及注射方式是实验顺利开展的必备条件。今天小V就和大家一起来学习一下AAV在心脏研究中的优化策略,以提高AAV的基因转移效率。
+AAV在心脏研究中的靶向策略【应用篇】
+AAV在心脏研究中的应用及注射方法
+维真AAV病毒在高血压脑出血中的应用
心脏方面:
1.
Hypertension. (IF=7.713). Liu, Wen, Li, et.al. (2020). Oleic Acid Attenuates Ang II(Angiotensin II)-Induced Cardiac Remodeling by Inhibiting FGF23(Fibroblast Growth Factor 23.[中国医学科学院阜外医院 AAV9-Fgf23&AAV9-GFP 高血压心脏重构]
2.
International Journal of Molecular Medicine. (IF=3.098). Huang, et.al. (2019). Redd1 protects against post-infarction cardiac dysfunction by targeting apoptosis and autophagy.[华中科技大学同济医学院附属协和医院 AAV9-Redd1 & AAV9-GFP 心机梗死MI]
3.
Frontiers in Pharmacology. (IF=4.225). Shen, et.al. (2019). Downregulation of miR-146a Contributes to Cardiac Dysfunction Induced by the Tyrosine Kinase Inhibitor Sunitinib.[河北医科大学 AAV9-cTNT-GFP-miR-146a & AV-miR-146a SNT-诱导的心脏收缩障碍]
4.
Journal of Molecular and Cellular Cardiology. (IF=4.133). Wu, et.al. (2019). The protective effect of high mobility group protein HMGA2 in pressure overload-induced cardiac remodeling.[武汉大学 AAVs & Ads心脏重构]
5.
Biochemical and Biophysical Research Communications. (IF=2.985). Yang, et.al. (2018). Vaspin alleviates myocardial ischaemia/reperfusion injury via activating autophagic flux and restoring lysosomal function.[山东大学齐鲁医院 AAV-vaspin & Ad-RFP-GFP-LC3 心脏]
血管方面:
Arteriosclerosis, Thrombosis, and Vascular Biology. (IF=6.604). Zhao, et.al. (2019). ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension.[山东大学齐鲁医院 AAV2-SM22α-ALDH2 & AAV1-ICAM2-ALDH2 低氧性肺动脉高压HPH]
Journal of Molecular and Cellular Cardiology. (IF=4.133). Sun, et.al. (2019). LncRNA H19 promotes vascular inflammation and abdominal aortic aneurysm formation by functioning as a competing endogenous RNA.[南方医科大学南方医院 AAV9-H19 腹主动脉瘤AAA]
Journal of Cerebral Blood Flow & Metabolism. (IF=5.681). Li, et.al. (2019). Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice.[中国医学科学院阜外医院 AAV9-LH3-p2A-GFP 高血压性脑出血ICH]
Arteriosclerosis, Thrombosis, and Vascular Biology. (IF=6.604). Zhong, et.al. (2019). SM22α (Smooth Muscle 22α) Prevents Aortic Aneurysm Formation by Inhibiting Smooth Muscle Cell Phenotypic Switching Through Suppressing Reactive Oxygen Species/NF-κB (Nuclear Factor-κB).[南方医科大学南方医院 AAV9-SM22α 腹主动脉瘤AAA]
客服电话 400-077-2566
备案号:鲁ICP备13011878号 网址:www.wzbio.com.cn