+维真AAV在妇科肿瘤研究中的应用
+维真生物shRNA病毒包装案例分享
+『CircRNA领域新发现』浙江大学范顺武教授课题组发现CircRNA :CircSERPINE2,为骨关节炎治疗提供有效策略
皮肤方面:
1.
International Journal of Biological Sciences. (IF=4.858). Wu, et.al. (2019). Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.[温州医科大学附属第二医院 AAV9-U6-shRNA (Prkaa1)-CMV-EGFP 随意皮瓣]
肾脏方面:
EBIOMEDICINE. (IF=5.736). Liu, et.al. (2019). H19 promote calcium oxalate nephrocalcinosis-induced renal tubular epithelial cell injury via a ceRNA pathway.[华中科技大学同济医学院附属同济医院 AAV9-H19 肾钙质沉着症]
2.
Science Translational Medicine. (IF=16.304). Wang, et.al. (2018). Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway.[南方医科大学 AAV9-MIR-GFP-lnc-TSI 肾纤维化]
肺脏方面:
Cell Death & Disease. (IF=6.304). Zhang, et.al. (2019). circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA.[上海市第一人民医院 AAV6-circHIPK3 shRNA & scrambled shRNA 肺纤维化]
Oncotarget. Tian, et.al. (2017). Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling.[华中科技大学同济医学院公共卫生学院 AAV-Sirt6 特发性肺纤维化]
体外实验:
Retrovirology. (IF=4.183). Wang, et.al. (2017). Genome modifcation of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection.[武汉大学基础医学院 AAV-SaCas9-CXCR4-gRNA HIV基因治疗]
巨噬细胞方面:
EBioMedicine. (IF=5.736). Lian, et.al. (2019). Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway. [北京大学 AAV2-ADAM17-GFP & AAV2-GFP 主动脉夹层AD]
Circulation Research. (IF=14.467). Fu, et.al. (2016). Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Defciency Drives Atherosclerotic Calcifcation. [北京大学 AAV2-integrin β3 & AAV2-β-tail domain & AAV2-GFP 动脉粥样硬化AS]
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