消化系统 - 维真生物-病毒包装_腺相关病毒_腺病毒_神经递质探针_jGCaMP7_AAV血清型筛选_慢病毒_LV_ADV_|AAV_逆转录病毒_光遗传_化学遗传_CRISPR/Cas9_自噬_细胞稳定株筛选_质粒载体

研究领域

当前位置：首页 > 研究领域 > 消化系统

AAV在肝脏研究中的靶向策略（干货篇）

+脂肪肝如何走上纤维化？江苏大学附属武进医院严永敏教授 Autophagy（IF 14.3）发文揭示胞外囊泡UBQLN1调控MASH肝纤维化分子机制
2026-06-08

+肝脏里的“隐形卫士”：石河子大学张云华、朱井玲团队揭秘ANGPTL6如何掐断TGF-β1/Smad3纤维化“信号链”
2026-06-10

+浙江大学/瑞金医院团队揭示DJ-1/CAV1通路通过坏死性凋亡调控结肠炎的机制
2026-06-11

+重医大附二院龚建平/蔡东团队构建新型VRK评分，为肝细胞癌预后预测与精准治疗提供新标志物
2026-06-11

肝脏方面：

1.	Proc. Natl. Acad. Sci. U.S.A. (PNAS). (IF=9.412). Zhang, et.al. (2020). Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation.［中国人民解放军军事医学科学院 & 南开大学 AAV-DJ-CAG-Cre II型戊二酸尿症GA-II］
2.	Journal of Hepatology. (IF=20.582). She, et.al. (2019). PSMP/MSMP promotes hepatic ﬁbrosis through CCR2 and represents a novel therapeutic target.［北京大学基础医学院 AAV8-hPSMP & null 肝纤维化］
3.	Theranostics. (IF=8.579). Liu, et.al. (2019). Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration.［浙江大学 AAV9-CMV-YAP 肝再生］
4.	Molecular Cell. (IF=15.584). Wan, et.al. (2019). Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.［浙江大学 AAV9-mCherry-GFP-LC3 and AAV9-Pacerwt-HA&Pacer2KR-HA&PacerS157A-HA&PacerS157D-HA 肝自噬和脂代谢］
5.	Experimental Cell Research. (IF=3.383). Li, et.al. (2018). Brg1 promotes liver fibrosis via activation of hepatic stellate cells.［华中科技大学同济医学院附属同济医院 AAV8-shBrg1 or AAV8-GFP 肝纤维化］
6.	Molecular Cell. (IF=15.584). Wan, et.al. (2018). mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.［浙江大学 AAV9-shHUWE1 & shNC and AAV9-WIPI2&WIPI2-S395A&WIPI2-S395D 肝自噬］
7.	Molecular Cell. (IF=15.584). Su, et.al. (2017). VPS34 Acetylation Controls Its Lipid Kinase Activity and the Initiation of Canonical and Non-canonical Autophagy.［浙江大学 AAV9-CMV-VPS34&3KR&3KQ 肝自噬］
8.	Proc. Natl. Acad. Sci. U.S.A. (PNAS). (IF=9.412). He, et.al. (2017). MicroRNA-351 promotes schistosomiasis-induced hepatic fibrosis by targeting the vitamin D receptor.［第二军医大学 AAV8-CMV-eGFP-miR-351-5p Sponge 血吸虫病肝纤维化］

试用装免费申请

免费咨询电话

400-077-2566

备案号：鲁ICP备13011878号网址：www.wzbio.com.cn

丨免费试用装丨

×